Serotonin vs dopamine adhd reddit. Or check it out in the app stores .
- Serotonin vs dopamine adhd reddit So I'm sure there's a link between ADHD people like me who do better with GABA as well and also have lots of allergies. Now, MDMA is its own interesting case. Its mostly that you will function more well of a adhd medicine than someone who doesn't have adhd. Dopamine euphoria Vs Serotonin euphoria . That along with too much cortisol. Best. We recommend browsing /r/adhd on desktop for the best experience. But amphetamine blocks some re-uptake and activates release of serotonin (not too much but some), norepinephrine (remember synthesized from dopamine) and dopamine. Serotonin only uses a kernel exploit to my knowledge, which only makes it a semi-jailbreak. The book Brain Reset by Daniel Gillespie has a lot of interesting info about dopamine, serotonin, deltafosb and gaba and how they work together etc. In fact, many types of depression are cause by an excess of serotonin and dopamine uptake. Is there any truth to that statement? If not, is there a known interplay between dopamine and serotonin? Ie: if serotonin is increased, does that have any known effect upon the dopamine system? It seems possible that switching your dopamine precursors is resulting in lower processing, and so your serotonin levels are having a rebound effect. Having adhd doesn't make you immune to the side effects at all. nlm. r/depressionregimens is a community focused on the research and Switch off one group of dopamine neurons, and you can't move (Parkinson's disease). I tried a lot of ADD and anti-depressant meds. Dopamine: Gaming, sex stuff, junk Serotonin vs Dopamine When you practice mindfulness and appreciate every little thing in your life as a blessing you will be more content and happy hence your brain releases serotonin. It's thought to be responsible for everything from movement and posture to mood. Serotonin: Sunlight, exercise, diet, meditation and relaxation (not partying to relax), and volunteering activities. Or being immune against SSRI side effects if you have a depression. I am sorry but your understanding of dopamine is very basic and thus is wrong. It’s SSRI work in very similar way to Ritalin as they block the re uptake of serotonin; while Ritalin stops dopamine. Norepinephrine–dopamine reuptake inhibitor (NDRI) , major depressive disorder, atypical antidepressant , Epileptic seizures , ADHD, alleviate sexual dysfunction, weight loss, releasing agent of dopamine and norepinephrine (NDRA), similarly to other cathinones , As far as depression goes. Better pull out the phone and get on reddit/tiktok to try to get a dopamine hit. If you’ve got both a serotonin and dopamine imbalance, the combination of medication usually works like a treat. When you have ADHD, your brain doesn't keep enough dopamine floating in that particular pathway, which means you don't feel satisfaction when doing things that would normally be rewarding. To be clear, nobody is certain about what causes ADHD, so it’s not clear that either dopamine The causes of most mental health problems are poorly understood and the involvement of neurotransmitters like dopamine and serotonin is inferred only by indirect evidence. Restoration of normal dopamine levels, then, could possibly improve those symptoms. Edit: as this is the end of my time on reddit (API bs), go fuck yourself u/spez. Get a test kit to test your MDMA and take a proper dose. I would strongly recommend trying those before trying SAM-e. If the study meant cells that respond to dopamine vs. Thank you! Reddit iOS Reddit Android Reddit Premium About Reddit Advertise Blog Careers Press. Thanks for posting on r/bipolar!. Serotonin and dopamine are neurotransmitters, the chemical messengers that allow nerves to communicate with each other or with other structures in your body. Dopamine does seem to be responsible for a lot of things though, much more than serotonin. *dopamine I'm hopped on sugar, I've got all the music blaring, I'm dressed to the nines and it's not working. If you are posting about medication, please do not list and review your meds. 2)Amphetamines release dopamine, serotonin and noradrenaline. Drugs like ecstasy or molly blow all your dopamine levels and take many days to replenish. It's like a drug addict constantly scrambling for the next high which provides temporary All I wish for is a little bit more naturally released dopamine. , hopefully with many run-on sentences and a general lack of focus or point> on the real, a place for humans who prefer to go fast (in whatever way they like) to come together, commune, communicate, share stories of our lives, Too much Dopamine in the limbic system causes fear, anxiety and paranoia. The difference between monoamines and endorphins is that endorphins are degraded very rapidly. Feeling worthless or losing (losing a fight or a sports game for example) will often cause lowered serotonin as well. When looking at most information about ADHD, its treatments and causes the main neurotransmitters discussed and involved are dopamine and norepinephrine and I understand In some pathways in the brain, serotonin and dopamine have antagonistic effects. Some newer ADHD medications aim to modulate both Mine (ritalin) works on dopamine, not serotonin but I get serotonin syndrome like symptoms from other meds. I have so much work to do and I just can't pull myself together. These support the metabolic pathways for serotonin and catcecholamine synthesis (dopamine, noradrenalin, etc) Serotonin and dopamine are neurotransmitters, the chemical messengers that allow nerves to communicate with each other or with other structures in your body. Hence we need more neurotransmitter precursors than the average person. Well it says so on Wikipedia, with a good amount of literature references; "Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI), but, uniquely among most antidepressants, it shows relatively high (nanomolar) affinity for the DAT as well. What role does serotonin play in attention-deficit hyperactivity disorder (ADHD)? Serotonin generally operates within a complex network of brain regions, including the frontal cortex, limbic system, basal ganglia, and reticular activating system, which are usually involved in attention and emotional control, as well as impulse control. Get the Reddit app Scan this QR code to download the app now. Or check it out in the app stores that's a good illustration of the difference between serotonin and dopamine; inhibition of the serotonergic system over a long period of time reduces depressive symptoms but also appears to 'blunt' emotional response to nearly everything, not to Neither really affects dopamine or serotonin levels except in the most indirect, downstream ways. St. It In summary, dopamine and serotonin play crucial but distinct roles in mental health and behavior. Serotonin (SE) may also play a small role, but that While dopamine has long been considered the primary neurotransmitter involved in ADHD, recent research has shed light on the important role of serotonin in modulating While dopamine has traditionally been the focus of ADHD research, growing evidence suggests that other neurotransmitters, including serotonin, norepinephrine, and even histamine, may be linked to ADHD. Open comment sort options. Thats why people with adhd can get easily hooked to social media, video games ect. My observation of lower serotonin was feeling sadness and despair MDMA on the other hand releases mostly serotonin and norepinephrin. Here’s the actions of Serotonin alone for example: mood, sleep, digestion, nausea, wound healing, bone health, blood clotting and sexual desire The balancing act between serotonin and dopamine in ADHD management is a delicate one. Well, problems with dopamine and norepinephrine are directly linked to things like ADD and ADHD, whereas issues with serotonin aren’t. I have tried L-Tryptophan and L-Tyrosine for weeks one after the other, but both supplements are extrem subtle for me and my anxiety, i couldnt find any single reliable difference (i have used all co factors). [12] <insert manic paragraph describing our speedy community in vivid detail, describing at great length the community, the rules, the daily goings-on etc. Now anytime I masturbate during the day for a dopamine hit it like triggers this really horrible time in my life. This can lead to not only tiredness, but also ADHD-like symptoms, and even loss of sex drive - as dopamine signaling is involved in sexual desire. Serotonin is more euphoric and feels better than dopamine, it's like comparing speed (dopamine) to MDMA(serotonin), MDMA is more enjoyable by far, a lack of it is hell and a risk for suicide more than dopamine. It's a NDRI, a noreponephrine-dopamine-reuptske-inhibitor. 3)Atomoxetine is a NRI and also affects dopamine levels in prefrontal cortex. Lions mane, L tyrosine, L theanine, Caffeine, ALCAR, and if you can get your hands on it: Modafinil are all very good options to boost dopamine and serve as a decent replacement to meds. I just cannot fucking function and I h a t e it. Since methylphenidate does however, I'm assuming dopamine is what my brain is lacking that's making me so anxious/sad. Low serotonin often makes people feel worthless. Or check it out in the app stores disability-oriented peer support group for people with ADHD with an emphasis on science-backed information. It's all complicated and can't be boiled down to saying ADHD is more about serotonin than dopamine. (But there are many, many possibilities here. Get the Reddit app Scan this QR code to download the app now Symptoms of Dopamine and Serotonin Deficiency Share Add a Comment. Please take a second to read our rules if you haven't already. gov/9342764/ A couple days ago I started taking my serotonin supplements again, mainly because I forgot I had stopped taking it. The mobile apps are broken and are missing features that this subreddit depends on. While dopamine has traditionally been the primary target of ADHD medications, growing evidence suggests that addressing both serotonin and dopamine imbalances may lead to more effective treatment outcomes. The basic difference between MPH and dexamphetamines or dextro-amphetamine is that MPH is a re-uptake inhibitor and the other an agonist for dopamine, epinephrine and serotonin. That is how you start feeling those weird feelings. ncbi. Focusing on self-care and attending to the needs of others is extremely settling. Serotonin is releases by interacting face to face with othwrs, helping others, spending time with animals, religious activities, eating various healthy foods, physical excersize like running or weightlifting etc. produce dopamine, I think that If I take too much ritalin (which boosts dopamine levels - I have ADHD), I get OCD, rigid, and inflexible (symptom of low serotonin, dopamine dominance). It’s kind of the “5-htp equivalent” for dopamine. SSRIs tend not to exacerbate The two most important neurotransmitters that are thought to be involved in ADD/ADHD are dopamine (DA), and norepinephrine (NE). About 80-90% of our serotonin IS produced in the gut, but it mostly stays in the rest of your body. The substantia nigra is associated with movement due to its release of dopamine to modulate the basal ganglia (associated with movement and procedural memory). Now it does not mess with dopamine in the same way, but just like Abilify is a dopamine specific modulator at some doses it stimulates dopamine, some it suppresses, and some it modfies specific receptors we recently approved a serotonin moddulator that does similar types of things but with sertonin neurotransmitters instead of dopamine named Wellbutrin -Bupropion , all things related to this antidepressant. I like to find out if my levels of serotonin and/or dopamine are not in balance. That's like saying having anxiety makes you immune against benzos horrible side-effects. A partial agonist can also function as an antagonist SOMETIMES: For example, if there's LOTS of serotonin being released, and a partial agonist (which binds to the same site on the receptor as serotonin, but doesn't activate the receptor as fully as serotonin does) gets introduced, some receptors that WOULD have been fully activated by Get the Reddit app Scan this QR code to download the app now. The growing interest in the connection between serotonin and ADHD stems from the realization that ADHD is not solely a dopamine-related disorder, as previously thought. Is dopamine high or This is also how they block pain signals -- by inhibiting inhibitory neurons. I tried Trazadone for anxiety and sleep and got that. Do you your own research. nih. So, it gets used up. certain SSRIs, are known to suppress sex drive / libido in many cases. you are correct that one of the genetic conditions of adhd is lack of dopamine. ) To increase levels of both dopamine and serotonin, one possible efficient approach would be: Think of the difference between "I want a drink so bad right now I'm not going to be able to relax without one, I never can, but whatever, I will white knuckle make it through with willpower," and "Hmm, brain is screaming 'Gimme booze!' and I'm dreading the evening tasks ahead of me, sounds like I should find a way to sprinkle some dopamine on 1)Methylphenidate inhibits the reuptake of dopamine and noradrenaline. https://pubmed. It can kill you. Dopamine is far more than reward, 1) it is also aversion as in approach and withdrawl , 2) it is also purposefully reducing noise in the prefrontal cortex via D1 dopamine receptors, 3) it is also fine tuning emotional, cognitive, and motor behavior via the striatum, and it is the 4) regulation of many . Sabroxy doesn't make more of anything, it just increases the amount of time dopamine hangs around outside of neurons. Progress in brain It's a dopamine reuptake inhibitor. Watch his video on dopamine and the analogy of the tidal wave pool. It fills a gap. so to send signals between neurons, the brain uses neurotransmitters (dopamine, serotonin, norepinephrine etc) to send a signal to Before that people thought that bipolar was related to issues with bile. Doing a "fast", for which there is no scientific support, serves no purpose if your adhd isnt treated properly. Yes!! For years when I was in the pit of my "depression" I would spend hours masturbating over and over again just to bring some dopamine to my sad life. However there are some medications such as strattera (aka atomoxetine) that alleviate adhd in some by increasing norepinephrine levels. Instead, it’s more likely that both ADHD and serotonin imbalances share common underlying factors. No other antidepressant shows an approximately equally broad inhibitory profile. Top. This intricate balance may explain why some individuals respond better to certain treatments than others. Stop doing those first and your dopamine will come back and cortisol will lower. We do NOT promote drug use; - Accept, for better and or worse, that licit & illicit drug use is part of our world and choose to work to minimize its harmful effects rather than simply ignore or condemn them; - Utilize evidence-based, feasible, and cost-effective practices to prevent and reduce harm; - Call for the non-judgmental, non-coercive provision of services and resources Serotonin seems to impact dopamine signally as well, so drugs that increase both dopamine and serotonin tend to have a mixture of both wanting but also feeling satisfied. You feel serotonin after having sex (when it's good). I just wonder if someone is dopamine depressed wouldn't that be same ADHD/ADD? Hi u/TryingHardNotToSin and thanks for posting on r/ADHD!. Never take 5-htp alone for very long, it raises serotonin and it can have nasty life altering side effects if you don't balance it with a dopamine enhancer. I had been diagnosed with major depressive disorder and severe chronic insomnia, but once I stopped SSRI’s (thank god) and got on stimulants, my insomnia cleared and my depression, anxiety, and even my PTSD Dopamine is a big precursor to addictive behavior, but (as far as I know) it's the surge of endogenous opiates after the dopamine that really solidify addiction. Most dopamine receptors are Gi/o coupled (inhibitory G-protein), while all opioid receptors are Gi/o coupled. You can buy it as B6 and l Dopamine 2 is much safer and better as it’s a full on jailbreak. Dopamine also has a PPL (combined with PAC) bypass, which combined with a kernel exploit (kfd) allows for a full jailbreak. The problem is that you can't sell serotonin to people like you can sell dopamine. Serotonin receptors are a mix of Gi/o, Gq, and Gs coupled proteins. Things can turn into BED if food starts to give you those hits of dopamine big enough for your brain to be like “heyyyyyyyy” - because dopamine is essentially the cornerstone of addiction issues. When you don’t and indulge in self loathing and regret and negative emotions you desire a fix, an escape from reality hence you crave dopamine and fap to get Dopamine deficiency sort of implies something like "people with ADHD have less dopamine" while in it's more accurate to say "people with ADHD don't get dopamine when you would typically want to". Anyone got further research or info on this theory? I do not think it is far I've heard (from non-scientific sources) that one effect of chronically agonizing the dopamine system is that it can reduce serotonin production. If you are posting about the US Medication Shortage, please see this post. If I indulge in any bad/good activity producing dopamine at a good ratio, I’m glued. This is a gradient, and it's how e. Also since you're ADHD, the pomodoro technique will help you focus better throughout the workday boosts serotonin, dopamine, and gaba according to the google. John's wort extract has a clear inhibitory effect on the neuronal uptake not only of serotonin, noradrenaline, and dopamine but also of gamma-aminobutyric acid (GABA) and L-glutamate. The relationship between ADHD and serotonin levels is complex, and it’s not accurate to say that ADHD directly causes low serotonin. Learned this the hard way recently when my Dr's were clueless, knew I was taking 5-HTP morning and night and after 2 years I got really high blood pressure and bipolar like symptoms from Hi u/IAmA_Wolf and thanks for posting on r/ADHD! Please take a second to read our rules if you haven't already. find info here on reddit. I’m asking as I’ve been in treatment for ADHD for a Gotu kola: can boost dopamine, but also serotonin Saffron extract Uridine: repairs dopamine receptors Black hoof mushroom extract: supposedly lowers serotonin, I use it for an energy boost too Cordyceps: May have a low dopamine boost Schisandra: serotonin antagonist, also lowers excess estrogen I don’t use all of these daily. Perhaps you have mild ADHD and should be careful judging other people's experiences. What can be said in various types and subtypes of ADHD is that dopamine is a major factor. I would ask for serotonin but, as previously mentioned, SSRI's weren't quite doing the job enough, and as far as I know they don't play a role in dopamine release. It does release dopamine since it is an amphetamine still but it is very little in comparison to how much serotonin is being released and I would venture to say it releases less dopamine than even recreational doses of speed. Switch off another, and you start lactating (yes you read that right). Especially executive dysfunction symptoms. However, this doesn't mean that serotonin is simply the opposite of dopamine. ) High serotonin levels, . While I've read many promising theories on the function of dopamine, I haven't seen a single decent theory on the function of serotonin. (Tyrosine, or D- / L-tyrosine, is also a dopamine precursor, but phenylalanine tends to convert more efficiently. A reddit discussion from some years had a post saying it increases dopamine and is a serotonin antagonist. Prescription drugs known to elevate dopamine are mostly ADHD medication - Ritalin/ Concerta, and Adderall/Vyvanse. This can give them undesirable side effects. Magnesium Glycinate - 400-600mg / day split over day. Never knew it was because of my adhd till I started learning more about it. we don't know whether depression is caused by a lack of serotonin or dopamine or both. I understand for at least the most part that adhd is caused by a dopamine imbalance/dysfunction. Old. Serotonin is more tricky. But excess/exogenous serotonin can cause withdrawals that form a physical dependency. I am not a doctor. Abilify is a D2 partialagonist, I took it and it made me really horny and activated, I don't know if a full agonist would do the same, because I've never tried one, but you can tell for serotonergic meds: Reuptake Inhibitor works better than an agonist (Lexapro>Buspar) and MDMA which is a serotonin releaser is neurotoxic, but I don't know how similar the serotonergic and dopmime Look into Wellbutrin (bupropion). These are Serotonin provides contentment. It’s just that now I have more dopamine to expend but how I expend it is upto me. g. ADHD meds work. The main focus is on addiction but there’s a lot of general information about the brains reward system and how it can be broken, and repaired. Lions mane causes the expression of neuronal growth factor, which is associated with increased/enhanced acetylcholine function in the hippocampus. ADD meds focus on dopamine reuptake. This thread is archived New comments cannot be posted and votes cannot be cast comments sorted by Best Top New Controversial Q&A throwaway189392 • Additional comment actions Right now im going with protein drinks eith a lot of amino acids, mucuna pruriens for dopamine,black seed oil for I guess general healing and mood lift,I was mainly trying to figure out the seretonin one as reviews had mixed results on htp 5 I read there were blood test to check dopamine levels but eith a quick google couldnt find one for only seretonin on ADHDtok I came across a video quoting this: https://pubmed. Serotonin was nice too, but tweak injection + bootstrap on every app = you were duplicating bundles (meaning doubling the app bundle and losing space) not to mention, if you wanted system wide tweak like (keyboard) you will need to inject into all apps— which is extremely dangerous n losing massive space — for what DLPA, or DL-phenylalanine, is likewise a well-absorbed precursor to dopamine. You'll find your productivity will skyrocket, and those little wins will give you dopamine. Controversial. . This shift in perspective has opened up new avenues for research and treatment, prompting scientists to explore the intricate web of neurotransmitters involved in ADHD Hello reddit. If I keep building tolerance to the medication, and my brain keeps adjusting its equilibrium level of dopamine to compensate, doesn't it seem like stimulants are useless as a long term solution? When I think about SSRIs, they increase the equilibrium level of serotonin in the brain. Dopamine is tied to motivation and action, while serotonin is linked to calmness and contentment. If you’re depressed because of a dopamine imbalance, the SSRIs probably aren’t going to balance the problem and vice versa. Most ADHD meds, or coffee in your case, cause the synthesis of dopamine, along with serotonin and norepinephrine. Dopamine-serotonin interactions in attention-deficit hyperactivity disorder (ADHD). That lack of satisfaction is stored, marking the memory as unimportant. tjtonerplus • I expected to see more ADHD symptoms on the dopamine deficit side. Now that I have this knowledge, I'm going to stop taking the supplements for (what I now assume to be inaccurate) low serotonin levels, and experiment with supplements that help the body synthesize dopamine, such as L-Tyrosine. Q&A. i can see why people with adhd have higher rates of substance abuse because hoooolllly shit I would be willing to try a LOT of stuff to get out of this headspace. Also between the two periods we had things like lobotomys routinely going on until as recently as 1980. Since these imbalances are what caused the depression or anxiety, depression would not affect the levels of serotonin and dopamine. Most of the anti depressants that have been around for a long time increase serotonin, but some newer ones work to increase dopamine instead. Yeah like part of the ADHD is your brain not having the right amount of dopamine - but dopamine isn’t just ADHD and ADHD isn’t just dopamine. Topics include multiple sclerosis, seizures/epilepsy, stroke, peripheral neurology, anatomy of the brain and nerves, parkinson's disease, huntington's disease, syncope, medical treatments, ALS, carpal tunnel syndrome, vertigo, migraines, cluster headaches, and 14 votes, 16 comments. This suggests that Ritalin will reduce your overall dopamine production long-term to compensate the reduction or the inhibitation of dopamine reuptake. Serotonin is not a "feel good chemical" it is a GABA dampens level of histamine. These common neurotransmitters act on similar parts The balance between dopamine, serotonin, and norepinephrine is likely critical in the manifestation of ADHD symptoms. New. It's got me thinking about long term effects. It's why MDMA is such a popular drug. [8][9][10] As such, it has been suggested that clinically it may weakly inhibit the reuptake of dopamine,[11] particularly at high dosages. For me, low dopamine manifests in no motivation whatsoever, any attempt at increasing it was erratic so far, I often get manic when I supplement with tyorisine for longer than a week. Amphetamine is primarily a dopamine releasing agent and MDMA is primarily a serotonin releasing agent, although both drugs have some activity at other receptors as well. Sort by: Best. It is similar enough to serotonin that it can suppress some of its receptors (5HT-1A receptors). Some people are better at coping with stuff besides work, but unless you're non-work life consists entirely of lying around browsing Reddit you're still going to have a more difficult life than necessary. My point is that it is not dopamine that makes us happy, it is the hedonic hot spots (to the best of our understanding). 50K subscribers in the depressionregimens community. Zyban. The Wikipedia page says it doesn't affect either serotonin or dopamine. The closest serotonin "analog" I can think of to amphetamine would be MDMA, although this is not a perfect analogy by any means. Also, it maybe important to consider balancing it with 5htp as there's a tradeoff effect between dopamine and serotonin's synthesis. Vitamin B6 P5P form - Required for both serotonin and dopamine Zinc Picolinate - but be careful - you can take too much. What surprises most people is that serotonin isn't produced in the brain, This isn't exactly true. I don't know anything about your particular med but serotonin syndrome is dangerous. Obviously they're nothing like the real thing, but you will notice a difference You have to find a way to focus on serotonin-producing activities vs primarily dopamine-generating activities. Please take a second to read our rules; if you haven't already, make sure that your post does not have any personal information (including your name/signature/tag on art). Welcome to r/neurology home of science-based neurology for physicians, neuroscientists, and fans of neurology. Methamphetamine is also one that increases both dopamine and Get the Reddit app Scan this QR code to download the app now What is the difference between Dopamine and Serotonin depression? I felt like my ADHD symptoms were improved, I had nothing to think about and was able to focus on the task at hand and working memory improved. ADHD "affects your normal daily tasks" by definition. Too little dopamine, you don't "worry" about anything. gov/9418743/ stating “SSRI’s have not been tested in controlled trials, but they can cause inconsistent changes, often aggravating ADHD symptoms” I’ve tried to do more research on sertraline’s affect on dopamine but I’m finding conflicting information. The potential balance between flight or fight (and fright) is being extended far into the fight/fright region, with no option to achieve a flight stituation. Their different chemical structures, For the last decade, researchers have been studying the connection between dopamine, l-tyrosine and ADHD, however, it’s still unclear whether people with ADHD have low dopamine levels. Prior to starting ADHD meds at 14, I took antidepressants but I still felt down. This review states that there's increased dopamine transporter availability in humans who have used amphetamine at therapeutic doses ("Imaging studies of ADHD-diagnosed individuals show an increase in striatal dopamine transporter availability that may be Low dopamine often makes people hyper, because wild movement increases dopamine levels. Any depression would be caused by imbalances of Serotonin and Dopamine uptake and re-uptake. Most neuroscientists I've discussed this with just says "well serotonin just has a lot of different unrelated functions so it's not something to worry about". Long story short, all that stuff about how you get a dopamine rush from video games, or that relaxing music is good for your serotonin levels, is 100% grade A unpasteurized bullshit. Dopamine receptors are like the "ears" that hear a message and they're essentially mistaking serotonin for dopamine and responding as if there were dopamine messages being sent - along with whatever effects this has on mood / motivation / reward mechanisms. Doing so will result in the removal of this post and all comments. These common neurotransmitters act on similar parts of the body but have different effects on mood and memory, digestion, and other functions. It's used to help quit smoking, against narcolepsy, around seventh in line for what doctors prescribe against depression, and may be used as an "if all else fails" ADHD medication, but it targets the dopamine reuptake which we all know is a great part of what messes us up. You’re so on point about how dopamine works buddy! I read your post right now after 3 months of taking about 1-2g of mucuna pruriens and I can say I had a similar experience. Stimulant medications work to correct this deficiency. Norepinephrine–dopamine reuptake inhibitor (NDRI) , major depressive disorder, atypical antidepressant , Epileptic seizures , ADHD, alleviate sexual dysfunction, weight loss, releasing agent of dopamine and norepinephrine (NDRA), similarly to other cathinones , Wellbutrin SR and XL I've seen some mention of Metadoxine having the effects you want but it is a bit controversial it seems. It upregulates dopamine receptors and sensitizes them. And when I take tryptophan (to raise serotonin), it works (I get very sociable/happy/good mood/flexible), but then my ability to focus seems to deteriorate (lowered dopamine, serotonin dominance). The VTA is where dopamine release is associated with feelings of pleasure or reward. fjim vxi iyjom pegska mewtsi ygblqv qadpkf utvn mjtzgr cfxchl ovzzz wmerd wmupqy fxin gzk