Undermethylation supplements reddit. I wasn't aware of this Niacin trick.
Undermethylation supplements reddit Supplement ~3-5g/day of creatine monohydrate or creatine hydrochloride (HCL). Consider taking the iron with a meal that has fruits, with juice, or with a vitamin c supplement. Since I've delved into the topic of MTHFR / L-metyhlfolate supplements, I've often heard something along these lines: You should avoid being "overmethylated", it will make you too euphoric Niacin will cause you to become "undermethylated", that Undermethylation Many patients with obsessive-compulsive tendencies, oppositional-defiant disorder, or seasonal depression are undermethylated which is associated with low serotonin neurotransmission. Inability to tolerate methyl donors generally indicates overmethylation. Not sure what that is related to, or why they thought B6 was necessary to supplement. I discovered I have an undermethylation problem that if you take it in large doses you need to also take TMG to support methylation so I took a methylated folic acid supplement and I almost immediately experienced mental clarity. The 5mg Folate supplement I found is by Now foods - which should be available globally. Traits: OCD tendencies, perfectionism, calm, competitiveness, self-motivated, accomplished, strong willed, high fluidity So I recently (as of last week) went back to the drawing board and dropped all my supplements and decided to give a sublingual Hydroxocobalamin solo supplement a try. Or check it out in the app stores Home This is what seems to be the effect on COMT due to MTHFR SNPs (which causes undermethylation). overmethylation. A majority of the rest of those who suffer from schizophrenia, anxiety and depression are undermethylated which results in LOW dopamine, serotonin & norepinephrine. The human body is very complex. This is on top of a whole foods plant based diet, rich in folate. You can be overmethylating one neurotransmitter sure. Brainfog, losing your train of thought, spacing out and losing things are all related to the executive functioning of your brain. This is a pearl on reddit! I search for something like this for so long! Impressive work! Question: Blood checks ramping up creatine and glycine takes time. And while I don’t subscribe to the entire worldview of Yasko, Lynch (who makes very good supplements BTW), and others in it’s entirety, there is quite a bit of good science to be had there. Hello there! This community serves a location to share material and thoughts related to solving "overmethylation". However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are now allowed as responses to this comment. B-vitamins, zinc, choline, creatine, vitamin D) and I’ve been taking this supplement daily without fail for probably 4 or 5 years now. I used to be able to handle high-dose methylation supplements as well as other nutrients that raise relevant monoamines. What I would do: If you haven't been supplementing you could do fairly routine bloodwork to see if it reveals anything: Iron panel, vitamin D (often low in B12D patients), serum B12 But taking SAMe supplement are expensive and have the risk of raising homocysteine levels, which is actually mitigated by TMG (and some B vitamins). Undermethylation is idiosyncratic and needs a lot of experimenting to get right. yes but you definitely build up tolerance to it. Under methylation supplement stack . ” It’s a pretty good-standard guide for navigating supplementation for these issues. But if you are dealing with motivation problems, addiction, low mood and anger issues (extremely unlikely that comes from only 500 mg of Tyrosine), I really need to say that therapy should maybe be the first avenue to explore together with maybe getting blood work done to get a proper idea about Get the Reddit app Scan this QR code to download the app now. Vitamins recommended for treating undermethylation naturally include calcium, magnesium, vitamin B6, and methionine. Did anyone experience an unexpected health issue to resolving after implementing supplements There are certain supplements that deplete methyl groups and TMG helps add those back. Reply reply Any help with supplements will be greatly appreciated. A few months back, the FDA sent out warning letters to many supplement companies telling them to retract the products as they no longer view the drug,I mean supplement (🙃) as not meeting the definition as just a “dietary supplement”. I know one thing that you need to pay attention to when taking SAME and that is to get in enough glycine since it might glycine to be wasted. Or check it out in the app stores A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. I take calcium, vitamin d, boron, zinc, copper, and tmg Just lay off supplements- you clearly can’t handle them. Members Online However I still cannot tolerate methyl donors. Which supplements should I take? Would TMG (or SAM-e) plus a methylated B Complex be enough for undermethylation issues? Are MSM, carnosine/beta alanine and sunflower lecithin good for undermethylation and high histamine and homocysteine? I suspect I have also slow COMT. I started Walsh protocol after a whole panel of blood tests via my functional psychiatrist. Get the Reddit app Scan this QR code to download the app now. In addition, magnesium glycinate can help support the COMT enzyme (clears monoamines). Discussion of nootropics and cognitive enhancers. Just started taking a b6 supplement, and noticed that my nasal swelling congestion (i. If you want to stay plant based look for plant based milks with Get the Reddit app Scan this QR code to download the app now. I used this company just to get my data to put into another site to learn more about mthfr and after a month I am still waiting for them to send a link for my raw data. This state can result from a variety of supplements (e. Raising one of them will often lower the other. If that still causes issues look for a multi with the "lessor" form cyanocobalamin as it will remove some methyl groups to process it. However, you can't supplement magnesium without supplementing calcium. 37 votes, 67 comments. Symptoms of undermethylation are the I bought a bottle to help me with benzo withdrawal symptoms but I read from someone that NAD+ alone can deplete methyl levels so I was suggested to buy trimethylglycine (TMG) to avoid undermethylation. Taken with your folate supplement, B9, and really Bs in general, is recommended for better health. Over methylation is very uncommon. Another thing that can contribute to undermethylation besides the MTHFR gene mutations and environmental causes, are high levels of histamine in the body. Hyper Activity, low libido, nervous legs and pacing, dry mouth and eyes, belief others thinks ill of them, low motivation for school, high pain threshhold (though always in pain), depression, sleep disorder, tinnitus all my life, upper body/neck/head Let me review your medications and supplements to ensure you are taking what is right for your healing process. For supplements you may just want to fill gaps created by any food aversion, for example if you are not eating a lot of vegetables then a Greens supplement could make sense if it is well-tolerated. I suspected b6 due to the tingling and testing confirmed my levels were too high. Best of luck! Causes of Undermethylation. Choline Calcium Magnesium View community ranking In the Top 10% of largest communities on Reddit. View community ranking In the Top 1% of largest communities on Reddit. Some people due to genetic mutations naturally have these Is it necessary to supplement a B Complex, when taking SAM-e for undermethylation issues, in order to avoid the increase of homocysteine? What about this article that startes that SAM-e could be toxic? The reasoning is simply that in the long run it could lead to over-methylation? glycine has been a miracle for me. Undermethylation & Histamine. I have no idea how to start. Not a place for discussion of illicit and illegal compounds. BTW, the supplements are great. Supplementing SAM when undermethylated helps make up for the deficit and so may be useful, but once methylation is normalized, then supplementing SAM may lead to overmethylation side effects. Members Online I have many undermethylation symptoms and I'm trying to find a way to do genetic test here in Italy. These supplements help balance neurotransmitter levels and Discussion on the relative pros and cons for supplementation are accepted and encouraged. In my years communicating this issue, the so-called symptoms of over- or undermethylation unsurprisingly overlap with common deficiency and/or "start up" reactions. I didn’t realize the brain fog, terrible fatigue, sleep issues, hair loss (and more) were due to b6 until I stopped it. (BHMT patway) Phosphatidylcholine is formed by methylation. . Because of this, I was told that it is smart to supplement TMG with niacinamide in order to combat the negative effects of the B3. ; SAM-e SAMe (s-adenosyl methionine) is a naturally occurring amino acid manufactured from methionine, which is found in protein-rich foods, and produced by the liver. I'll speak with an immunologist. g. I most likely have already have high levels of folic acid. Thank you for your comment and insight. They will probably make some supplement recommendations, and you can read about them to see if you want to take them. Yes, exactly right. You should otherwise be fine with normal B12 supplements. If you have the MTHFR mutation, homozygous, as heterozygous is not an issue, or have low folate levels you definitely should supplement with B2 as it is very important for flavoenzymes Common supplements for improving methylation include SAMe and methylated B vitamins, which help increase the methyl group of methyl groups. Another thing I tried was taking a beef kidney supplement DAO enzyme for several months (Ancestral Supplements brand), but didn't find that it made a difference. :D I hope you feel better soon. If you know for a fact that undermethylation is the problem, taking a targeted nutritional approach is your best bet. Their bodies are calibrated to undermethylation. . You do NOT have to take the full dosage. Pooja says. Or check it out in the app stores Is it possible to treat/correct an undermethylation issue with dietary changes alone or are supplements always needed? Share Add a Comment. Or check it out in the app stores A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. Same with any high choline source. I’m still figuring it out though too. Just add a K2 supplement as it is missing entirely, and an additional magnesium supplement. They generally exhibit seasonal allergies, perfectionism, competitiveness, and other distinctive symptoms and traits. Reply. my subreddits. Technically, I do use non-fortified nutritional yeast, which has some B vitamins, but isn't really a supplement per se. Now, why am I no longer able to take these I do have some of these gene variations and I saw very profound effects when I started playing around with supplements and diet to support the methylation. I used to do well on inositol but nope not anymore. ) Remedy to Undermethylation Get the Reddit app Scan this QR code to download the app now. That doesn’t mean that you shouldn’t take niacin; I personally trend toward undermethylation but I still take it, and it does in fact give me an immediate sense of motivation. So if anyone has experience with supplementing with TMG I would like to hear about your experience (ie: dosage, mood, side effects, other benefits, etc). B-vitamins, zinc, choline, creatine, vitamin D) and The only supplement I know that can help with cognition is omega 3 oil, but never min that, see a doctor. edit subscriptions. From my understanding, you want to be as close to undermethylation as you can get without actually negatively impacting metabolic processes, since hormones are also affected by methylation. Lastly, I'm not a doctor, and this is not medical advice. I have symptoms from both OVER and UNDER, and when I read the symptoms of each I recognize my symptoms. You also need to not eat foods high in cadmium and arsenic like chocolate and rice to not cause a inhibition of the enzyme CYP27A1. However never took SAME directly. Also, reading a lot about overmethylation vs undermethylation helped a lot. At some point you just have to accept that no matter what the genetic test says, your body has the final say. Strong willed: Another characteristic that is found among those who are undermethylated is that of a strong will. Background. 5 and my vitamin B leveles are normal-high. Glutathione – Low glutathione levels can impair I've recently been tested for my methylation type. You'll also likely benefit from reducing histamine in your diet. However, discussions or rants declaring a supplement or supplement regimen useless based An Undermethylation Diet. What did you expect them to do, go to a supplement Reddit sub, start researching anecdotal bro science and prescribe you a b complex? They didn’t do that because that doesn’t work Reply reply Google overmethylation and undermethylation. One phosphatidylcholine supplement capsule will overmethylate me for a week and kick me into histamine overload. I understand we are on a supplement subreddit. That being said, bloodworks showed that I have high histamine and high homocysteine. Reddit gives you the best of the internet in one place. Undermethylation is the more desireable, though it's also not optimal. Go to Supplements r/Supplements • by PATHAN-ZONDRA. Supplement L-methylfolate and B12. Question about I was taking high doses of methylation supplements (Thorne MethylGuard) and noticed that I lost all motivation to do any thing. If L-methylfolate isn't helping, you could have a B12 deficiency - take sublingual B12 (in a nature bioidentical form: methylcobalamin and/or adenosylcobalamin, not I did take methionin as a supplement and this was the last thing in a row of supplements that triggered a MCAS flare with panic attacks. Or check it out in the app stores TOPICS. The causes of undermethylation are typically a combination of the following: Protein deficiency (undermethylators do not do well on low animal protein diets such as vegan and vegetarian) Malabsorption; Histamine overload (gut health is big factor) Genetic mutations (MTHFR, MS, COMT, etc. Hi guys, I've seen that SAM-e (or creatine) could be useful for both slow COMT and undermethylation. Does any of it ring a bell? A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. I dont know what to do now, I took high dosages of zinc and vitamin C for a week bc i was sick but i dont know if that have anything to do with my methylation status. I have high anxiety, depression, paranoia up to a point, insomnia, which are OVER, but I also have fatigue, addictions, depression and insomnia, which can be UNDER. I stopped taking the supplement but I felt that way for months. Supplements should just be there to fill in the gaps or for specific purposes. I had to incrementally take 500mg (100mg every hour or so) to finally feel normal. A few things. I did benefit from those 3 supplements: TMG, SAMe and Methyl-B12 (noticed only positive Otherwise try to get B12 from non-supplement forms. undermethylation? If you look up symptoms of both states, you might find Also, my symptoms my whole life seem to match undermethylation except since I've been sick they match overmethylation. I came across a reddit post that said that if you’re going to supplement Methylfolate, you should also be supplementing B12, Vitamin D, Vitamin B6 and B3. Good luck getting stronger and glad to hear you found a supplement that makes a difference! But if you are folate deficient, then you are not creating adequate methylfolate; hence, the undermethylation. Or check it out in the app stores Seems one has to do with undermethylation and the other has to do with overmethylation. and overmethylation vs. I think the issue of taking it frequently enough is especially an issue with SAMe supplements. The u/Undermethylator community on Reddit. These supplements can support energy production and overall health. When my mood feels flat; when I’m a little anhedonic, that tells me I need more methyl donors. April 20, 2024 View community ranking In the Top 20% of largest communities on Reddit. Do you peeps supplement anything like However after using NMN at 1g per day for 4-5 days in a row I started to get symptoms of "undermethylation" where I basically just felt extreme fatigue and could barely get out of bed so I decided I needed to increase methylation, but this time decided to try TMG instead Been saying this for good, and questioning people, some of who take around 5 gram of choline from their daily lipo supplements, but no one could provide answer to my concern, and a supplement company here on reddit said there isn’t enough research about this topic and/or (forgot) whether or not all that choline would be converted to TMAO . While I could be off base, I would have thought that this is caused by a reduction in acetate. If I want to align to the theory of undermethylation/ overmethylation, I was a classic undermethylator prior to administration of methylfolate. If you are undermethylator, your phosphatidylcholine levels have decreased. According (may also be a symptom of undermethylation) High energy Highly creative (especially in musical ability) copper supplements may exacerbate symptoms, while zinc supplementation may be helpful This shit isn't funny nor is this pain constructive. As a vegan I hate to say it but you might just be the person that really requires things like eggs in your diet to get to that level of B12. Foods and supplements high in retinol/carotenoids,vitamin B6 and seed oil are for me the most problematics and the things you need to avoid at all cost as all three convert inevitably into toxic aldehydes. My doctor says undermethylation is also most likely present in a lot of poisers and undermethylation can alone cause histamine and dopamine issues. And I swear I'm not getting any kickbacks. Does undermethylation cause slow COMT? Ive read that low methylation could contribute to less efficient COMT activity, the enzyme that uses a methyl donor to methylate catecholamines like dopamine. if this enzyme is less able to “eat” dopamine, you could postulate that in For anyone wanting to get dna testing don’t use 23andMe. It’s a give take as undermethylation is high histamine and histamine is a wakefulness promoting and cognitive promoting neurotransmitter, however overmethylation is more dopamine which is good for energy motivation etc. (or even from liposomal products) Undermethylation could possibly be a clue as to why. Any anecdotal comments elsewhere in the Base on all testing, consultation and reasearch POIS would probably be more undermethylation, but this shitt is so complex that I quit and basically take what I felt it helps. I want it lower. Or check it out in the app stores which leads to undermethylation, and adding methyl folate can fix this undermethylation. From March 16, 2021, until today, I’ve been taking: 15mg MethylPro (which also contains 250 mg of Glycine) 50mg B6 P-5-P 300mg Nicotinamide Riboside Chloride (TRU NIAGEN) 125 mcg D3 First, simply waiting and not taking any more related supplements or enriched foods should help reduce symptoms as the body gets a chance to clear away the monoamines. The risk you run is having too many methyl groups i. It cracks me up to see people on here who are quartering or more their folinic acid supplements, taking the absolute smallest amount because their body won't tolerate any more. So take folate supplements, right? That’s personally what I do. These all further support methylation I have many symptoms of undermethylation (mainly anxiety, overthinking, brain fog, some repetitive behaviors, disturbed sleep due to high REM). I take 2400mg of NAC daily. My doctor suggests just sticking with mast cell stabilizers and my Under methylation supplements. In terms of digestion support you could consider digestive enzymes and/or ginger. It can get really ugly if you're in that neurotransmitter-imbalanced headspace buying every supplement that offers a chance at relief just be careful with your mental health and make sure you keep up with has anyone here, particularly undermethylators, felt an unexpected increase in energy and mood right after taking nicotinic acid? I demonstrate all or most of the symptoms of undermethylation, especially high histamine, anxiety, depression, etc, but when I take a small dose of niacin (100mg) as nicotinic acid, I feel a strong increase in motivation, energy, and mood. New comments cannot be posted. Basic Description: The term “overmethylation” describes the experience of negative side effects generated from an increase in methylation-related nutrients. I did test high for b12 at one point but mostly my blood work has been good. The research though is still Lin early stages. 629umol/L) a reliable diagnostic tool for diagnosing undermethylation. This is because high histamine levels and undermethylation are associated. Undermethylation induced depression suffers should avoid folic acid as it can further reduce serotonin levels even though it can assist with methylation. So, yeah, seems to be a pretty delicate balance for people with MTHFR / COMT issues. Yes, I now used iodised salt and eat eggs. I recommend adding a zinc supplement of your choice. Walsh. I am not sure about my MTHFR status yet, but I assume I am an under-methylator, and trying supplements to lower Hcy: Took B12 injections, feel much better. I spend tons of money to not be sure about anything. Get the Reddit app Scan this QR code to download the app now magnesium, vitamin B6 and methionine as well as very high levels of folc acid in blood are the signs of undermethylation. You should look at all your symptoms to find out if you are over- or under-methylated. The methylation cycle "spins" about 18,000 times/day. Also, I took the 7 mg methylfolate yesterday (6S) and I feel god awful today. The lack of iodine is just you having a low iodine diet and being scared to supplement which is dumb. I always get out of I should add that the Genesite test stated: Homozygous T Allele of C677T Polymorphism, Significantly Reduced Folic Acid Metabolism, Significantly Decreased Serum Folate Levels, and Significantly Increased Homocysteine Levels. I’ve had issues digesting for years now, that combined with my heart and energy issues seem to 394K subscribers in the Nootropics community. copper, and magnesium. What is the smallest amount of supplements I could take to treat undermethylated schizophrenia naturally? 112 votes, 168 comments. Search Reddit for fish oil and depression or brain fog and you’ll see many people reporting this. I'm hoping TMG can prevent this. , 2004) 74. Majority of people are undermethylators and this also implies that they are copper toxic and copper deficient. You can read up on overmethylation and undermethylation. I don't know how to pull myself out of this, I'm extremely confused. Some people genetically have overmethylation or undermethylation so B12 and folate can tip Histamine intolerance is undermethylation. Could it be the additives in the folate? For some reason the manufacturer has added holy basil extract, though I can't imagine they having such an effect I allegedly need 9 egg yolks as well, but I’m allergic to eggs and extremely sensitive to methyl donors. The more I read about gene variants and their potential outcomes, the less I think, that there is a straight way, that Overmethylation is what you don't want. The list Think of them as another resource for yo8 to make your decisions. Here are some of those precursors and cofactors you should add to your diet to help with your undermethylation: Choline – An important methyl donor. Undermethylation. as well as doing more research on undermethylation. You need a ratio of minimum 1/1. So I might be in overmethylation but also Pyroluria?Like I have almost zero from the undermethylation table but lots from over. It's a better manufacturing process. Do you think that the following supplements could help with high histamine? SAM-e (I was going to start this anyway for undermethylation) DAO (I was thinking about trying NaturDAO) Quercetin Bromelain I always knew i had something wrong with me and spent thousands $$ and wasted years trying to find out, had an arsenal of supplements but after the tmg experience, this is the main supplememt for me that is not a supplement but more essential, i get it in bulk now :). I take Minami brand. Riboflavin kept supporting the methylation process till I began to be able to tolerate methyl One key point I'm confused about is why people with slow COMT are often told to improve their methylation cycle or supplement with a downstream chemical like Sam-E? I'm confused because I took 400mcg of methylfolate every day for 2 months and felt on-edge and anxious for most of it. Vitamin A came up, and turns out it works! Taking supplements that boost s-adenosylmethionine levels ("methylation supplements") can cause many kinds of negative symptoms depending on your body, but the main point is that too much SAM can be a bad thing, one way or another. Internet Culture (Viral) Amazing; Animals & Pets the variants for the disease and the deficiencies then it is going to be pretty important for them to blood test and supplement to prevent the disease. Creatine production uses about 40-45% of SAM from methylation, so supplementing creatine frees up endogenous SAM for other uses. Vitamin D uses magnesium to be converted in the body, and most of Try one a day in the am. e. Look up symtoms for overmethylation and undermethylation. I’m just so scared of supplements now because I always react very poorly I think doses on supplements are WAY too high. Many fish oil brands on our shelves are rancid and of little help. Could issues like low libido, hair loss, general male hormonal issues (weight accumulation around estrogen band area/butt/hips, muscle A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. Thank goodness for reddit! I had been feeling suicidal after taking phosphadityl choline in a large dose for several weeks. I wasn't aware of this Niacin trick. I would feel so horrible after a hard workout and a 50g protein meal (specially of whey). But this made me feel like trash, which could be its fault or something else entirely. Unbalanced diets as well. Hi all, I got a blood test for a methylation profile and I am awaiting the results on this. I've been getting a headache whenever I take over 1g of Niacinamide. Hence, I do not supplement anymore except for Vitamin D3 when the sun is not around. The B2 I was originally using was 400mg/day but I am currently trying out 100mg/day. Most people aren’t keen to down pharmaceutical medications once they have pinpointed the problem of undermethylation. Again, I'd focus on diet, using an app like Cronometer, to make sure that you are getting good coverage of all your vitamin and mineral needs. nasal passage congestion due to tissue swelling, NOT due to mucous) significantly decreases not long after take the b6 supplement. Planted-based (non-heme) iron in supplements needs vitamin c to be absorbed. P5P activated B6 supplement - 1x 50mg Vitamin D3 - 1 x 4000iu daily Calcium / Magnesium / Zinc Powder - 2x tsp daily Hello there! This community serves a location to share material and thoughts related to solving "overmethylation". Methylation is carried out by specific enzymes, each one using specific I see supplementing choline recommended as a way of supporting methylation but no defacto way of doing it. I’ve started using this liquid sunflower lecithin supplement so I can microdose choline. The exact amount you need depends on a variety of factors - start with 500mcg L-methylfolate a day and dial in a dosage that works for you. Filed Under: Treatments, Uncategorized, undermethylation Undermethylation has been implicated in various diseases, autoimmune conditions, cancer etc. Is it correct? Locked post. Recent bloodworks showed high From what I've understood, usually an undermethylator has low dopamine and serotonin, thus he could boost methylation and the production of neurotransmitters by supplementing B vitamins Since I began this regimen over 2 years ago I noticed that my body reacts badly to a number of supplements such as glycine, L arginine, citrulline, magnesium, DHEA and few Vitamins recommended for treating undermethylation naturally include calcium, magnesium, vitamin B6, and methionine. Overmethylation looks a lot like POIS. On the subject if taurine, I don't tolerate taurine supplements well at all, so that may be explained by CBS. Personally, I don’t buy into the over/undermethylation as a whole. for discussion of illicit and illegal compounds. This is an expert doctor on that subject, W. I also take a B complex that provides 400mcg of folate. Abstract: Vitamin B2 (Riboflavin) supplementation might be a potential solution for “overmethylation”. My symptoms are not typical for tyramine intolerance, though (usually high BP and/or migraines). I make my own homemade vitamin water consisting of 8 cups of water, 1 teaspoon of magnesium ascorbate powder (for the Vitamin C), and the powdery contents of 2 Nutricost Vitamin B complex Apparently Niacinamide causes undermethylation and raises histamine and homocysteine. If this is the case, should I get a methylated or standard B Complex? I discovered TMG(Trimethylglycine) and i'm using it for about 1 month, it's improves my energy and mood immensely and last a lot longer than b12, the reason i started it was the effects of this supplements regarding methyl groups in the body and how it's supposed to help anyone with this condition, so far it's working very well. And I'll get My conclusion is that I actually have undermethylation, not overmethylation, and taking creatine freed up methyl groups which worsened my symptoms initially. I can tell when I need to take them based on how I feel. I tested high in homocysteine - 12. Copper to Zinc ratio may be a bit high for most these daily vitamins. Your significant other may be a crazy whack job on occasion, but that alone doesn’t mean they need to be downing buttloads of methyl donors for the Get the Reddit app Scan this QR code to download the app now. popular-all-random-users | AskReddit One could try these supplements if undermethylation is suspected. Want to hear something interesting/strange: One year I started having excess vagal symptoms (ear fullness/soreness, dizzy, jaw soreness) while I was on a bunch of supplements; it was also spring and I had mild allergy symptoms. Whats You r experience with this topic and supplements. My level was 330, a bit low, but normal, but some people suggested to hike it to 350+, 500 is better. it says: Itis a life changer for me, turned out i am an undermethylator and happened to be consuming high protein diet for body building which made things much much worse. undermethylation thing is a bit iffy to begin with. Asked chatgpt: For someone with fast COMT activity, here are three supplements that may help support dopamine levels: L-Tyrosine : This amino acid is a precursor to dopamine and can help support its production, especially in individuals with fast COMT activity. "SAMe is very promising for undermethylated persons and a bad idea for those who suffer from a genetic tendency for overmethylation. I find this overmethylation vs undermethylation complicated. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not intended) purpose. If I've understood correctly, generally is advised to take SAM-e with a B complex, in order to avoid raising homocysteine. It’s very complex. I had all of your symptoms from b6 toxicity. Abstract: Vitamin B2 (Riboflavin) supplementation might be a potential solution for “overmethylation” . However there’s issues with this, too. true. Do you already supplement? Neurological issues can also be from low b12. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any intended (or not Welcome to r/science!This is a heavily moderated subreddit in order to keep the discussion on science. Undermethylation causes similar symptoms and many patients with mental illness such as anxiety, depression, schizophrenia, ADHD, autism, Alzheimer’s disease, Aspergers syndrome, OCD, as well as other conditions, have undermethylation. NAC is one of the only supplements that work. These are the three sources I read about this subject: one, two, three (Yes I know 2 of them are blogs but apparently they are based on research from the Walsh institute). Now idk if I am playing with too much stuff given my current stack and I don't know if my psychiatrist will know about these supplements. i don't really find time to take it a lot because someone on reddit said something about it messing with blood sugar and turning test subjects pre-diabetic (didn't bother reading the study tbh) - so i only take it at minimum 2 hours after eating and minimum 2 hours before - because allegedly then it doesn't mess as I am wondering if addressing undermethylation may help alleviate some of my symptoms but I'm also worried about personality changes induced by fixing undermethylation. Undermethylation can cause deficient choline. Abstract: In the following sections I explain why lithium orotate may help prevent "overmethylation" side effects caused by relevant nutrients such as folate, B12, choline, etc. About a year ago I got deathly ill from the Covid vaccine (possibly had Covid at the same time) and as I slowly recovered I noticed my libido was gone. Even though the whole over- vs. High homocysteine levels also indicate undermethylation. I do add coq10, pqq, shilajit, tongkat ali, some magmesium, zinc, niacin etc. But this said I'm not very experienced here, this is just what I Supplements for Undermethylation. I have to totally avoid methyl vitamins/methyl donors because they make me really sick since my methylation is so messed up. I make sure to do a lot of research before taking a new supplement. I am also a fan of adding extra vitamin C. I overmethylate very easily so I’ve bought all my supplements in liquid form so I can basically microdose them. jump to content. A number of people have stated that taking a relatively high dose of the nutrient for a prolonged period has resulted in a cessation of negative side effects from relevant methylation or monoamine-related supplements. Members Online • Bigpoppapenguin123 . The Sam-e made a positive difference within days - felt calmer, less reactive to stress or small irritations and energy more stable and longer lasting. Supplements for undermethylation Hill Calcium Magnesium methionine Omega-3 fatty acids B12 vitamin Vitamin C Results of taking medications Antihistamines: Since patients with undermethylation tend to have high histamine levels, the use of an antihistamine may result in favorable effects. Each time methylfolate gets used it gets for methylation by the MTR enzyme it gets converted to unmethylated tetrahydrofolate (THF). This is what happened to me and why my pois got so much worse after taking antihistamines for a month. I was reading this post in a other sub. I am homozygous for the C677T MTHFR mutation (this is the worst mutation combination to have - very much undermethylation). That way you can read up on symptoms. Some supplements are toxic to the body, who knows what fillers and heavy metal toxins are present in these Posted by u/myepicdemise - 2 votes and 4 comments A few weeks ago there was a thread discussing ways to increase GNMT function. It boosts methylation William Walsh, Nutrient Power (New York, NY: Skyhorse Pub. That leads me to think my symptoms are more tyramine related than histamine. Sorry I’m new to Reddit and don’t know how to link other posts (if others read this and know the post I’m talking about, pls link it), but search “MTHFR: A Supplement Stack Approach. If you’re doing well on supplements that support methylation, experiment with zinc, omega 3, glycine, and creatine. Some people are naturally overmethylators which might benefit from taking a few things that reduce methylation. I've heard that 90% of ocd cases are from I quit all the supplements and taking now vitamin D3 because my levels are 32 and i life up north, last week my homocysteine was 9. I take a high dose methyfolate supplement everyday which supplies 8500mcg of folate. Social isolation: Some individuals with undermethylation may isolate themselves from others and prefer to be left alone, especially during the completion of work. r/Supplements. From what I've understood, high histamine and homocysteine are related to undermethylation. Given that acetyl-CoA is an essential nutrient for both the citric acid cycle and the acylation of choline into acetylcholine; and that acetate can improve symptoms of depression it seems probable this is partially relevant at least. It seems like I just need to make sure I'm getting B2, B3, Zinc. A bit of background: I've read lots of books and articles over the past three years but specifically one of them, Dirty Genes, made me think I was A cheaper alternative is centrum silver 50+, which has most of what you need. It appears I'm an under-methylator, but I'm not sure what it all means and what I could be doing better with Can overmethylation and Undermethylation swings a lot throughout the day? so you experience both on a day but on different time? Not normally, however you could with too many supplements. Methyl B12 is Dangerous for some people! The reason why Methyl B12 is causing these strange effects (anxiety, feeling of doom, shortness of breath, palpitations and high blood pressure) is plain and simple. I'm just a fan. e. Professor Pfeiffer, an expert in this field, considers basophil counts greater than 50 cells/cu mm and histamine levels greater than 70 ng/ml (0. Manganese, copper, DMAE and choline may also worsen depression symptoms and thus should also be avoided in The only vitamins I currently supplement are B2 and B9. be used only when there is an issue with its methylation (MTR gene SNP). After 3 years of chasing histamine, genetics, and finally realizing i was having overmethylation and LOW histamine , with histamine producing gut infection Citrobacter and proteus, which complicates it future, I did niacin and I felt better but then tried collagen, NOT pure glycine, which is not found pure in nature, but collagen, which is , is Feeling good after taking methylfolate does not indicate undermethylation. Supplements for Undermethylation. Undermethylation cause low vitamin B6,B12 levels and high View community ranking In the Top 10% of largest communities on Reddit. personally think increase histamine with gingko omega 3 and increase dopamine with Sam-e Korean red ginseng & zembrin or ultra Kanna). Did you notice something after just one day? I do not see the point of taking that much methylfolate for anyone, at least not if you are undermethylated. COMT = Catechol-O-Methyltransferase, which metabolizes DA. A number of people have stated that taking a relatively high dose of the nutrient for a prolonged period has resulted in a cessation of Now, the issue is to supplement with folate or folic acid which has shown to lower homocysteine and increase SAM:SAH ratio, which is what you want essentially. Also note that you can report problems with supplements to the FDA. While continuing to very slowly titrate up B12 and B1. B12 likely Supplement with: Methionine Methionine is an amino acid precursor to SAM-e. I think of it as my “cross things off my to-do list” supplement! It’s just more important for you to go slowly, not much higher than your threshold for flushing. Carnivores, for For undermethylation he recommends the following supplements: Calcium, methionine, tri methyl glycine, magnesium, Fish oil, B6, SAMe, inositol and vitamins A, C, and E. The FDA does not regulate supplements as drugs, which means companies don't have to submit proof of safety and effectiveness for a specific use, but the FDA is interested in knowing if a supplement is making you sick. B complex supplements usually have B6 and B9 levels below the Tolerable Upper Intake, so you're probably safe there. But I find it hard to believe that all of them are simultaneously being over expressed or under. Some people more slowly recalibrate to higher Sure, the supplement that has made me feel far more mentally clear has been PCOSITOL by Delfran It has methylfolate and Methylcobalmin as well as inositol in the right ratio. iwjxn hgix nfmas mgyf venoph asow ieopjq mheo mqceqxg ylbpzq